NADPH Oxidase 2

An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.

Also Known As:

CYBB Protein; Chronic Granulomatous Disease Protein; Cytochrome B-245 Beta Chain; GP91-PHOX Protein; NOX2 Protein; Cytochrome B 245 Beta Chain; GP91 PHOX Protein; Oxidase 2, NADPH

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - NADPH Oxidoreductases NADH
      - NADPH Oxidases: 4427
        NADPH Oxidase 2: 207
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - NADPH Oxidases: 4427
      - NADPH Oxidase 2: 207
  - Flavoproteins: 240
    - NADPH Oxidases: 4427
      - NADPH Oxidase 2: 207

E Cifuentes-Pagano Selected Research

E Cifuentes-Pagano Research Topics

Disease

Drug/Important Bio-Agent (IBA)